Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Danshen, a Traditional Chinese Medicine, mitigates septic shock in patients by regulating the expression of Orosomucoid 1

Weizhang Zhong¹, Guangjun Jin², Li Yu³

¹Department of Critical Care Medicine, Xiamen Hospital, Beijing University of Chinese Medicine, No. 1739 Xianyue Road, XiaMen, Fujian 361009, China; ²Department of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318 Chaowang Road, Hangzhou, Zhejiang 310005, China; ³Department of Infectious Disease, Tiantai People's Hospital of Zhejiang Province, No. 1 Kangningzhong Road, Shifeng Street, Tiantai, Zhejiang 317200, China.

For correspondence:- Li Yu Email: y13967608784@163.com

Accepted: 24 December 2021 Published: 31 January 2022

Citation: Zhong W, Jin G, Yu L. Danshen, a Traditional Chinese Medicine, mitigates septic shock in patients by regulating the expression of Orosomucoid 1. Trop J Pharm Res 2022; 21(1):169-175 doi: 10.4314/tjpr.v21i1.25

© 2022 The authors.
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Abstract

Purpose: To analyze the effects of the components of the traditional Chinese medicine (TCM), Danshen, in the treatment of patients with septic shock.

Methods: The expression profiles of three experiments on septic shock, two therapeutic experiments, and one experiment associated with TCM treatment were collected to probe into the genes related to septic shock and regulated by TCMs. Function as well as protein-protein interaction (PPI) analysis were performed with the co-regulated genes related with septic shock.

Results: Precisely 187 co-regulated genes associated with septic shock were observed, and were enriched in the immune response, defense response to the bacterium, as well as infection and immune pathways. Ten (10) critical genes (RETN, LCN2, ELANE, LTF, MMP8, SLPI, ARG1, HP, PGLYRP1 and ORM1) were obtained. ORM1 expression was statistically stimulated under the treatment of the mixture of four TCM components in Danshen, and an increase of ORM1 expression was shown in septic shock patients being treated with hydrocortisone.

Conclusion: The mixture of four TCM components in Danshen has the potential to alleviate the conditions of septic shock patients by upregulating the expression of ORM1.

Keywords: Sepsis, Septic shock, Traditional Chinese medicine, Danshen, Orosomucoid 1, Hydrocortisone